TerminatedNot Applicable

Impact of Treatment of Periodontis on Endothelial Function in Patients With Obstructive Sleep Apnea

Stopped: Insufficient recruitment

France49 participantsStarted 2014-03-24

Plain-language summary

Evaluation of the add-on effect on endothelial dysfunction of treatment of periodontitis in patients with chronic periodontitis and severe obstructive sleep apnea treated by CPAP. Patients with and without chronic periodontitis will be treated by CPAP for 20 weeks. At V2 (10 weeks), endothelial dysfunction will be assessed by the Reactive Hyperemia- Peripheral Artery Tone index. The endothelial dysfunction of the patients will be also assessed at V3 (20 weeks) after periodontitis treatment for the group of patients with chronic periodontitis.

Who can participate

Age range30 Years – 70 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * severe OSA defined by an apnea hypopnea index \> or = 30 per hour * with or without chronic parodontitis Exclusion Criteria: * non equilibrated diabetes * obesity (BMI \> or = 40) * active smoker (\> 1 pack per day (20 cigarettes)) * pregnancy * antibiotics within the preceding three months * prophylactic antibiotherapy required for the parodontitis treatment * acute parodontitis or all parontal pathology requiring immediate therapy * less than 10 teeth

What they're measuring

Endothelial function

Timeframe: 20 weeks

Trial details

NCT IDNCT02573116

SponsorHopital Foch

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2016-12-22

View on ClinicalTrials.gov More Cardiovascular Disease in Obstructive Sleep Apnea trials