CompletedPhase 4

Staph Household Intervention for Eradication (SHINE)

United States835 participantsStarted 2015-10

Plain-language summary

The investigators propose a pragmatic comparative effectiveness trial evaluating several decolonization strategies in patients with Staphylococcus aureus infection, their household contacts, and household environmental surfaces. The central hypothesis of this proposal is that an integrated approach of periodic personal and household environmental hygiene will reduce S. aureus transmission in households and subsequently decrease the incidence of skin and soft tissue infections (SSTI).

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients 18 years of age and younger * Confirmed (i.e., culture-positive) active or recent (within the past 2 months) S. aureus cutaneous infections * Reside within 75 miles of St. Louis Children's Hospital * Provide written, informed consent, or consent is provided by a parent or legal guardian Exclusion Criteria: * Patients with nosocomial infections (i.e., \>48 hours after hospitalization) * Patients with traditional risk factors for HA-MRSA (e.g., immunodeficiency, indwelling catheter or percutaneous medical device, undergoing dialysis, presenting with a surgical site infection, or residing in a long-term care facility within the past year). * Patients who are unable to give consent or for whom consent is not obtained * Patients refusing home environmental cultures by the study team * Patients without a permanent home (e.g., living in a shelter or group home)

What they're measuring

Number of Households With at Least One Skin and Soft Tissue Infection

Timeframe: 3 months after randomization

Trial details

NCT IDNCT02572791

SponsorWashington University School of Medicine

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-11

Results submitted2025-10-28