TerminatedNot Applicable

Clinical Effectiveness of Frozen Thawed Embryo Transfer Compared to Fresh Embryo Transfer

Stopped: very slow recruitment

China138 participantsStarted 2015-10

Plain-language summary

The objective of the present randomized controlled study is to compare clinical effectiveness and safety of freezing all embryos followed by frozen-thawed embryo transfer (FET) compared to fresh embryo transfer, in women undergoing IVF treatment.

Who can participate

Age range

18 Years – 42 Years

Sex

FEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Women under 42 years of age * Presence of at least 3 embryos suitable to freeze on day 2 or 3 following fertilisation based on the centre's criteria * Written informed consent Exclusion Criteria: * Women using donor eggs/donor sperm * Women undergoing preimplantation genetic diagnosis * Women with abnormal uterine cavity shown on hysterosalpingogram or saline infusion sonogram * Women with hydrosalpinges shown on scanning and not corrected treated * Women with excessive ovarian response at risk of ovarian hyperstimulation where elective freeze is already planned * Women with serum progesterone level on day of human chorionic gonadotrophin\>1.5ng/ml or 5 nmol/L * Women whose embryos have not survived freeze-thawing in the past * Fresh transfer is planned e.g. patients with endometriosis or adenomyosis who have received prolonged downregulation * Only frozen transfer is planned e.g. patients receiving ovarian stimulation regimens which may have adverse impacts on the endometrium

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Live birth rate

Timeframe: up to 24 weeks

Trial details

NCT IDNCT02570386

SponsorThe University of Hong Kong

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2018-12

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