TerminatedPhase 4

Routine Antibiotic vs. Directed Antibiotic Treatment in Snake Bite

Stopped: Slower than anticipated recruitment and emergent COVID-19 situation

India66 participantsStarted 2016-05-03

Plain-language summary

Clinicians tend to overuse antibiotics in snake bite despite evidence from three previous clinical trials that failed to show a benefit. But, none of these trials was done in India. Further, the species of snake in two of these trials was quite different from that seen in the Indian setting limiting generalization of these findings. Hence, home-grown evidence is needed to persuade clinicians to use antibiotics rationally.

Who can participate

Age range18 Years – 65 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age 18-65 years * History of snake bite with features of local envenomation with/without systemic features * Less than 24 hours since bite, AND * No prior antibiotic treatment Exclusion Criteria: * Upper limb bites * Multiple (\> 1) bites * Wound manipulation * Extensive local necrosis or blebs * Seriously-ill patients with hypotension/capillary leak/life threatening bleeding. * Suspected cobra bite, OR * Pregnant/breast-feeding women

What they're measuring

Clinical failure

Timeframe: up to 4 weeks

Antibiotic consumption

Timeframe: up to 4 weeks

Trial details

NCT IDNCT02570347

SponsorJawaharlal Institute of Postgraduate Medical Education & Research

Sponsor typeOTHER_GOV

Study typeINTERVENTIONAL

Primary completion2019-10-24

View on ClinicalTrials.gov More Snake Bites trials