Routine Antibiotic vs. Directed Antibiotic Treatment in Snake Bite (NCT02570347) | Clinical Trial Compass
TerminatedPhase 4
Routine Antibiotic vs. Directed Antibiotic Treatment in Snake Bite
Stopped: Slower than anticipated recruitment and emergent COVID-19 situation
India66 participantsStarted 2016-05-03
Plain-language summary
Clinicians tend to overuse antibiotics in snake bite despite evidence from three previous clinical trials that failed to show a benefit. But, none of these trials was done in India. Further, the species of snake in two of these trials was quite different from that seen in the Indian setting limiting generalization of these findings. Hence, home-grown evidence is needed to persuade clinicians to use antibiotics rationally.
Who can participate
Age range
18 Years – 65 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age 18-65 years
* History of snake bite with features of local envenomation with/without systemic features
* Less than 24 hours since bite, AND
* No prior antibiotic treatment
Exclusion Criteria:
* Upper limb bites
* Multiple (\> 1) bites
* Wound manipulation
* Extensive local necrosis or blebs
* Seriously-ill patients with hypotension/capillary leak/life threatening bleeding.
* Suspected cobra bite, OR
* Pregnant/breast-feeding women
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Clinical failure
Timeframe: up to 4 weeks
2
Antibiotic consumption
Timeframe: up to 4 weeks
Trial details
NCT IDNCT02570347
SponsorJawaharlal Institute of Postgraduate Medical Education & Research