Minocycline and/or Omega-3 Fatty Acids Added to Treatment as Usual for At Risk Mental States (NCT02569307) | Clinical Trial Compass
CompletedPhase 2
Minocycline and/or Omega-3 Fatty Acids Added to Treatment as Usual for At Risk Mental States
Pakistan326 participantsStarted 2015-10
Plain-language summary
This is a randomized double-blind placebo controlled trial which aims to evaluate the efficacy and tolerability of minocycline and Omega-3 fatty acids for patients with ARMS. Specifically to determine whether the addition of minocycline and / or Omega-3 fatty acids to Treatment as Usual in an operationalized ARMS population in Pakistan:
Who can participate
Age range
16 Years – 35 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. Male and female help seeking individuals aged between 16-35 years.
. Meets at least one of the criteria for ARMS (see CAARMS Operationalized Intake Criteria section below).
. Assessed as competent to provide informed consent.
Exclusion criteria
. History ofpreviously experiencing a psychotic illness (treated or untreated).
. IQ \< 70 and/or history of learning disability.
. Any pre-existing inflammatory conditions e.g. rheumatoid arthritis.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
. treatment with an antipsychotic or mood-stabilising agent.
. Prior history of intolerance or serious side effects (hepatotoxicity, photosensitivity, blood dyscrasias) to any of the tetracyclines or Omega-3 fatty acids.
. Concomitant penicillin therapy or concomitant anticoagulant therapy.
. Active substance abuse (except nicotine or caffeine) or dependence within the last three months, according to DSM-V criteria.