UnknownNot Applicable

Intra-graft Coagulation Events in Clinical Renal Transplantation and Delayed Graft Function

Finland100 participantsStarted 2015-06

Plain-language summary

The purpose of this study is to investigate local activation of the coagulation system in the kidney graft during organ preservation and during early reperfusion in adult kidney transplantation. Generation of thrombin and fibrin as well as activation and inhibition of fibrinolysis will be investigated. Influence of these events on delayed graft function (DGF) and acute cell-mediated rejection will be evaluated.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * adult person (over 18 years old) * cadaveric transplantation * conventional standard immunosuppression plan (methylprednisolone, cyclosporin A, mycophenolate mofetil) Exclusion Criteria: * previous kidney transplant * other than local standard immunosuppression * panel reactive antibodies (PRA) \>30% * warfarin therapy * dual anti-platelet therapy * use of low molecular weight heparins (LMWH) or fondaparinux during last two weeks before surgery for other indication than hemodialysis

What they're measuring

Trans-renal difference/ratio of plasma concentrations of coagulation measurements

Timeframe: Two minutes after reperfusion of the kidney transplant

Delayed Graft Function

Timeframe: During 1 week after kidney transplantation

Acute cell mediated graft rejection

Timeframe: During 3 months after kidney transplantation

Trial details

NCT IDNCT02568696

SponsorHelsinki University Central Hospital

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2018-12-31

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