Association of Dipping Pattern or Early Morning Surge of BP With Asymptomatic Episodes of Paroxys… (NCT02563379) | Clinical Trial Compass
UnknownNot Applicable
Association of Dipping Pattern or Early Morning Surge of BP With Asymptomatic Episodes of Paroxysmal Atrial Fibrillation in Subjects With Hypertension (DIMOSPAF)
Greece200 participantsStarted 2015-09
Plain-language summary
The goals of our study are to determine a).the association between abnormal circadian BP and the development of paroxysmal AF in hypertensive patients, b).at which level of TOD, paroxysmal AF episodes are detected in hypertensive subjects, c).if there is any association between systolic and/or diastolic BP levels with AF occurrence, d).whether the mean heart rate during a 24-hr interval is associated with the development of paroxysmal AF, and finally e).examine the relationship between a wide PP and asymptomatic AF episodes in patients with HTN.
Who can participate
Age range18 Years – 85 Years
SexALL
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Inclusion Criteria:
* Patients diagnosed with essential HTN (office BP\>140/90mmHg) or patients receiving at least one antihypertensive medication (ie. RAAA inhibitors or diuretic), aged 18-85 years of age.
* Patients with at least one of the following risk factors, organ damage or other evidence of cardiovascular disease:
* Previous stroke
* Transient ischemic attack (TIA)
* Systemic embolism
* Diabetes mellitus type 2
* Obesity
* Obstructive sleep apnea (OSA)
* Dyslipidemia
* History of coronary artery disease (CAD)
* Valvular heart disease (VHD)
* Echocardiographic findings attributed to HTN (ie. diastolic dysfunction, LVH)
* White coat hypertension (WCH), masked hypertension (MH)
* Positive family history for rhythm disturbances
Exclusion Criteria:
* Patients already diagnosed with paroxysmal or permanent AF
* Severe renal insufficiency (eGFR according to MDRD formula \<25ml/min/1.73m2)
* Patients unable to attend follow-up visits
* Clinical evidence of severe heart failure
* Suspected secondary HTN
* Mental disorders
* Patients with cancer
What they're measuring
1
Association between nighttime BP patterns and/or early morning surge with the development of asymptomatic episodes of paroxysmal atrial fibrillation in hypertensive subjects