UnknownNot Applicable

Perfusion Imaging With Myocardial Contrast Echocardiography in HCM

United States10 participantsStarted 2015-12-01

Plain-language summary

The objective of this study is to determine whether myocardial contrast echocardiography in patients with cardiomyopathy (HCM) can detect resting hypo-perfusion due to fibrosis or stress induced perfusion defects due to associated abnormalities in intramyocardial arteries and the microcirculation. A secondary aim will be to determine whether abnormalities in perfusion are associated with either severity of symptoms (chest pain and dyspnea), presence of arrhythmias, and regional function of the septum.

Who can participate

Age range19 Years – 80 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age 18-80 years * Established diagnosis of HCM Exclusion Criteria: * Known history of coronary or peripheral artery disease * History of myocardial infarction * Pregnant or lactating females * Hypersensitivity to any ultrasound contrast agent * Evidence right-to-left or bi-directional intracardiac shunt * Moderate or greater valve disease other than from HCM (systolic anterior motion of the mitral valve) * History of septal ablation or myectomy * Hemodynamic instability * Pacemaker dependent heart rhythm

What they're measuring

Myocardial perfusion (ml/min/g) in the hypertrophied segment on myocardial contrast echo

Timeframe: One hour

Myocardial blood flow reserve in the hypertrophied segment on myocardial contrast echo

Timeframe: One hour

Trial details

NCT IDNCT02560467

SponsorOregon Health and Science University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2019-09-01

View on ClinicalTrials.gov More Hypertrophic Cardiomyopathy trials