TerminatedNot Applicable

How to Test Success of a Renal Denervation

Stopped: The Enterprise decided to stop the production of the catheter used for the clinical indicated renal denervation

Switzerland11 participantsStarted 2015-08

Plain-language summary

The study aimed to assess the success of a clinically indicated renal denervation by different tests and correlate the results of the tests with the clinical outcome.

Who can participate

Age range

18 Years – 85 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: Male and female patients 18 years to 85 years of age, with a diagnosis of re-sistant hypertension (office sitting blood pressure \>140/90 mmHg and 24-hour blood pressure \>130/80 mmHg in patients treated with at least three antihypertensive drugs including a diuretic) and a clinical indication for a renal denervation. Exclusion Criteria: * Secondary cause of hypertension * Anatomical contraindication to renal denervation (renal artery diameter less than 4 mm or more than 8 mm), multiple renal artery, length to bifurcation less than 2 cm * Heart failure (normal ejection fractions on echocardiography and no clinical signs and symptoms of heart failure). * Alcohol or drug abuse, * Malignancy (unless healed or remission \> 5 years) * Pregnancy * Know allergy to contrast medium * Participation in another study within the last month

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Response to adenosine infusion, cold pressure test, flow mediated dilation of renal artery before and 1 year after renal denervation B

Timeframe: chronic

lood pressure (office and 24-hour blood pressure), laboratory parameter before and 12 months after catheter-based renal denrevation

Timeframe: chronic

Trial details

NCT IDNCT02559882

SponsorUniversity of Zurich

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2018-12-21

View on ClinicalTrials.gov More Hypertension, Resistant to Conventional Therapy trials

Who can participate

Age range

18 Years – 85 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Response to adenosine infusion, cold pressure test, flow mediated dilation of renal artery before and 1 year after renal denervation B

Timeframe: chronic

lood pressure (office and 24-hour blood pressure), laboratory parameter before and 12 months after catheter-based renal denrevation

Timeframe: chronic