All participants in phase 1 and phase 2a had hand motion visual acuity or worse. If efficacy was demonstrated from phase 1, better vision subjects could be enrolled; however, efficacy was not demonstrated.
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Number of Participants With Any Grade 3 or Greater Adverse Event (AE) Considered Related to AGN-151597
Timeframe: Baseline (Day 1) to 6 Months
Visual Acuity in the Study Eye at Baseline and Month 6
Timeframe: Baseline (Day 1), 6 Months
Change From Baseline at Month 6 in Full Field Sensitivity in the Study Eye - Blue Light Threshold
Timeframe: Baseline (Day 1) to Month 6
Change From Baseline at Month 6 in Full Field Sensitivity in the Study Eye - Red Light Threshold
Timeframe: Baseline (Day 1) to Month 6
Change From Baseline at Month 6 in Full Field Sensitivity in the Study Eye - White Light Threshold
Timeframe: Baseline (Day 1) to Month 6
Change From Baseline at Month 6 in Ambulation in the Study Eye (Time)
Timeframe: Baseline (Day 1) to Month 6
Change From Baseline at Month 6 in Ambulation in the Study Eye (Distance)
Timeframe: Baseline (Day 1) to Month 6
Intraocular Pressure (IOP) Measurements in the Study Eye
Timeframe: Baseline (Day 1), 6 Months
Anatomical Parameters as Measured in the Study Eye by Color Fundus Photography and Autofluorescence
Timeframe: Baseline (Day 1), 6 Months
Change From Baseline at Month 6 in the Anatomical Parameters in the Study Eye as Measured by Spectral Domain-Optical Coherence Tomography (SD-OCT) - Total Retinal Nerve Fibre Layer Volume
Timeframe: Baseline (Day 1) to Month 6
Change From Baseline at Month 6 in the Anatomical Parameters in the Study Eye as Measured by Spectral Domain-Optical Coherence Tomography (SD-OCT) - Total Ganglion Cell and Inner Plexiform Layer Volume
Timeframe: Baseline (Day 1) to Month 6
Change From Baseline at Month 6 in the Anatomical Parameters in the Study Eye as Measured by Spectral Domain-Optical Coherence Tomography (SD-OCT) - Total Retinal Volume
Timeframe: Baseline (Day 1) to Month 6
Change From Baseline at Month 6 in the Anatomical Parameters in the Study Eye as Measured by Spectral Domain-Optical Coherence Tomography (SD-OCT) - Total Retinal Thickness
Timeframe: Baseline (Day 1) to Month 6