The emergence of multidrug-resistant bacteria has recently renewed interest in colistin. Data on dosing in critically ill patients undergoing extended dialysis are missing. The aim of this study is to determine the pharmacokinetics of colistin during extended dialysis in critically ill patients and to provide dosing guidelines for this drug.
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Colistin elimination during extended dialysis
Timeframe: Participants will be followed for 10 days. Colistin elimination measured by the total drug amount in the collected spent dialysate