CompletedNot Applicable

Bone Microcirculation After Remote Ischemic Preconditioning

Germany80 participantsStarted 2015-09

Plain-language summary

In trauma surgery and hand surgery treatment strategies of none healing bone fractures aim at replacing pseudarthrosis by well vascularized bone and improving microcirculation. Although previous studies indicate that remote ischemic preconditioning (RIPC) can accelerate bone healing in case of non-union, only a few studies focused on the elucidation of its mechanisms of action. Therefore, the aim of this study is to evaluate the microcirculatory effects of remote ischemic preconditioning (RIPC) on scaphoid bones and metacarpal bones and metatarsal bones in a human in-vivo setting for the first time.

Who can participate

Age range18 Years

SexALL

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Inclusion Criteria: * Group A (n=20): Consent-capable male and female patients ≥18 years of age who have an intact scaphoid bone. * Group B (n=20): Consent-capable male and female patients ≥18 years of age who have an intact metacarpal bone. * Group C (n=20): Consent-capable male and female patients ≥18 years of age who have a fractured scaphoid bone. * Group D (n=20): Consent-capable male and female patients ≥18 years of age who have a fractured metacarpal bone. Exclusion Criteria: * below 18 years of age * scar tissue above measuring focus * osteoporosis or comparable bone disease * medication that influences bones

What they're measuring

Change in microcirculation (composite outcome measure)

Timeframe: Baseline and 1 minute post-dose

Trial details

NCT IDNCT02554500

SponsorUniversity Hospital Schleswig-Holstein

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-02

View on ClinicalTrials.gov More Intact Scaphoid Bone trials