By InvitationNot Applicable

Effects of Stimulation Patterns of Deep Brain Stimulation

United States180 participantsStarted 2016-06-02

Plain-language summary

The purpose of this study is to measure the effects of non-regular temporal patterns of deep brain stimulation (DBS) on motor symptoms and neural activity in persons with Parkinson's disease (PD), essential tremor (ET), dystonia or multiple sclerosis (MS). These data will guide the design of novel stimulation patterns that may lead to more effective and reliable treatment with DBS. These data will also enable evaluation of current hypotheses on the mechanisms of action of DBS. Improving our understanding of the mechanisms of action of DBS may lead to full development of DBS as a treatment for Parkinson's disease and may lead to future applications of DBS.

Who can participate

Age range21 Years – 80 Years

SexALL

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Inclusion Criteria: * Diagnosis of Parkinson's Disease (PD), Essential Tremor (ET) dystonia or Multiple Sclerosis (MS) * Scheduled to undergo Deep Brain Stimulation (DBS) electrode implant, IPG implant or implanted pulse generator (IPG) replacement surgery * Neurologically stable * Able to understand the study and consent form Exclusion Criteria: * Inability to execute the motor tasks during the study * Inability to tolerate withholding anti-parkinsonian and/or anti-tremor medications * Clinically ineffective DBS

What they're measuring

Tremor Accelerometry

Timeframe: Day 1

Bradykinesia Finger Tapping

Timeframe: Day 1

Neural Activity

Timeframe: Day 1

Trial details

NCT IDNCT02553525

SponsorDuke University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-03

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