Active — Not RecruitingNot Applicable

Secondary Sclerosing Cholangitis in Critically Ill Patients

Austria140 participantsStarted 2015-12-21

Plain-language summary

SSC-CIP is increasing in patients after critical illness. Pathogenesis is still largely unclear. The investigators hypothesize that genetic variants of biliary transporter genes are frequent in patients with SSC-CIP. In approximately 140 patients and controls the rate of genetic variants in biliary transporter genes, gut permeability and gut microbiome as well as bone health will be studied.

Who can participate

Age range18 Years – 99 Years

SexALL

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Inclusion Criteria: * informed consent * Age above 18 years * secondary sclerosing cholangitis in critically ill patients Exclusion Criteria: * mechanical cholestasis * primary sclerosing cholangitis * primary biliary cirrhosis * Immune globulin G4 associated cholangitis * toxic cholestasis

What they're measuring

bile acid transporter genes

Timeframe: Day 1

Trial details

NCT IDNCT02545309

SponsorMedical University of Graz

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2026-01

View on ClinicalTrials.gov More Secondary Sclerosing Cholangitis trials