CompletedPhase 1

Efficacy of Bisphosphonates in Patients With Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis (SAPHO) Syndrome

30 participantsStarted 2015-10

Plain-language summary

This study is designed to evaluate long term efficacy of intravenous bisphosphonates for bone marrow edema in patients with SAPHO syndrome.

Age range18 Years – 70 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

✓. Male and female patients between the ages of 18 and 70 years
✓. Only 1 of the 4 inclusion criteria is sufficient to arrive at a diagnosis of SAPHO syndrome：
✓. MRI shows bone marrow edema in affected site in patients
✓. Blood serum of patients show the normal white blood cell count, liver and renal function
✓. Patients who like to be followed up for 1 years
✓. Other protocol defined inclusion criteria may apply

response to the treatment by the change of MRI result at screening, baseline, month 3 and month 6

Timeframe: 3 and 6 month (up to 6 month)

NCT IDNCT02544659

SponsorPeking Union Medical College Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2016-10