UnknownPhase 2

GnRHa Combined With hCG and hMG for Treatment of Patients With Non-obstructive Azoospermia

China30 participantsStarted 2015-12

Plain-language summary

Preliminary reports showed that hormonal treatment may improve the chance of retrieving viable testicular sperm from men with NOA. It was generally believed that gonadotrophin treatment would be ineffective in the presence of high plasma levels of endogenous gonadotrophin.The purpose of this study is to determine whether GnRHa(gonadotropin-releasing hormone agonist) combined with hCG(human chorionic gonadotropin) and hMG(human menopausal gonadotropin) are effective in the treatment of non-obstructive azoospermia.

Who can participate

Age range

18 Years – 45 Years

Sex

MALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Male subjects aged 18-45 with clinical diagnosis of non-obstructive azoospermia. * At least testicular volume more than 8.0ml on one side . * FSH more than 5.5 IU/L. Exclusion Criteria: * Subjects with anatomical abnormalities of the genital tract. * allergy to the drugs used for treatment. * Y chromosome deletions or abnormal karyotypes. * Subjects combined with cardiovascular, liver, kidney ,or hematopoietic system severe primary disease,or mental disease

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Sperm retrieval rate (SRR)

Timeframe: 4 months

Trial details

NCT IDNCT02544191

SponsorJinling Hospital, China

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2017-12

Contact for this trial

Bing Yao, MD

86-25-80860174 yaobing@nju.edu.cn

View on ClinicalTrials.gov More Azoospermia trials