The Association of Miltefosine and Pentoxifylline to Treat Mucosal and Cutaneous Leishmaniasis: A Clinical Trial in Brazil

Inclusion Criteria: * Mucosal and/or cutaneous leishmaniasis, not treated or at least 6 months without any treatment to leishmaniasis; * For patients with cutaneous lesions: duration of disease longer then a 1 month and shorter then 4 yeas; 1 to 3 lesions; larger lesions from 10mm to 50mm; * Ages between 18 and 80 years old; * Fertile female patients should use at least two contraceptive methods (hormonal and barrier); * Agree to participate in the study and sign the informed consent term. Exclusion Criteria: * Use of any leishmanicidal drugs six months prior; * Clinical or laboratorial evidences of electrocardiographic disorders; * Renal, hepatic, cardiac diseases, uncontrolled diabetes or AIDS; * Hypersensitivity to meglucamine antimoniate; * Pregnancy or lactation; * Fertile females that do not agree to use contraceptive methods; * Patients that do not agree to the informed consent term.