TerminatedNot Applicable

Aneuploidies in Embryos and Spermatozoa From Patients With Y-chromosome Microdeletions

Stopped: Insufficient recruitment

Spain5 participantsStarted 2015-09-22

Plain-language summary

In this study, investigators assess, using Fluorescence in situ Hybridization (FISH) and Comparative Genomic Hybridization (CGH) arrays for Preimplantation Genetic Screening (PGS), the incidence of aneuploidies in spermatozoa and embryos from infertile men with and without microdeletions who undergo assisted reproduction in their clinics.

Who can participate

Age range18 Years – 50 Years

SexALL

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Inclusion criteria

✓. Couples with male infertility whose man has non-obstructive azoospermia or severe oligozoospermia with ≤5x1000000 spermatozoa/ml.
✓. Assisted Reproductive Technology: ICSI with motile spermatozoa and PGS by CGH arrays.
✓. Women \<38 years if microinjection is carried out in their own eggs, or 38≤ age \<50 years if they receive donated eggs.
✓. Women with body mass index (BMI)\<30.
✓. Men\<50 years

Exclusion criteria

✕. Couples with abnormal karyotypes.
✕. Women with any uterine pathology or abnormality, hydrosalpinx, thrombophilia or systemic diseases at the time of embryo transfer that could prejudge the outcome of the cycle
✕. Couples with repeated miscarriages (≥2) or implantation failures (≥2).
✕. Couples whose men has obstructive azoospermia, genital tract infections (mumps, inflammation, varicocele), cryptorchidism, or if he receives any treatment that can reduce the sperm count.
✕. Seminal samples processed by Magnetic Activated Cell Sorting (MACS) technique.

What they're measuring

% Embryos with aneuploidies

Timeframe: three years

Trial details

NCT IDNCT02527954

SponsorInstituto Valenciano de Infertilidad, IVI Alicante

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2018-06-11

View on ClinicalTrials.gov More Male Sterility Due to Y-chromosome Deletions trials