TerminatedNot Applicable

Online Cognitive Training in PD, MS and Depressed Patients Treated With Electroconvulsive Therapy

Stopped: All Parkinson's disease patients have finished training. The MS and ECT groups have not finished as these groups had trouble including 20 patients.

Netherlands28 participantsStarted 2016-03

Plain-language summary

In Parkinson's disease, Multiple Sclerosis and depressed patients treated with electroconvulsive therapy, cognitive dysfunction is prevalent. However, treatment of these dysfunctions is in its infancy. The purpose of this study is 1) to assess the feasibility of a randomized controlled trial using an online computerized intervention for training cognitive abilities in the three patient groups and 2) to estimate the effect of the online training on objectively and subjectively measured cognitive functions. The investigators hypothesize that patients using online cognitive training will improve more on cognitive functions, as compared to patients using an active control condition.

Who can participate

Age range30 Years – 70 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: General criteria: * Patients have (access to) a computer with access to the Internet. Patients are capable of using a keyboard and computer mouse. * Patients are willing to sign informed consent. PD-specific criteria: * A compilation score of executive functions (i.e. Stroop, Trail Making Task, Fluency) shows deficit, which lies between 1 and 2 standard deviation (SD) below the mean of healthy Dutch norm population. * Patients are diagnosed with Parkinson's disease according to the United Kingdom Parkinson's Disease Society Brain Bank criteria. * Patients are in Hoehn \& Yahr stadium \< 4, and are medically stable during a month prior to the intervention. The medication will be attempted to remain stable for the remainder of the intervention. * Patients are 50 to 70 years old. MS-specific criteria: * A compilation score of episodic memory (i.e. Rey Auditory Verbal Learning Test, Location Learning Test) shows deficit, which lies between 1 and 2 SD below the mean of healthy norm population. * Patients have been diagnosed with MS for a period longer than three month prior to inclusion in this study according to the renewed McDonald criteria. * Patients have been on stable medication for at least three months. * Patients are 30 to 45 years old. PostECT-specific criteria: * Unipolar depressive patients indicated for ECT, who experience cognitive complaints after treatment with ECT. * Patients have undergone the full ECT-procedure. * Phonemic fluency and…

What they're measuring

Feasibility

Timeframe: 8 weeks

Trial details

NCT IDNCT02525367

SponsorAmsterdam UMC, location VUmc

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2017-06