Follow-up-study of COPD Patients and Healthy Controls for Evaluation of Predictive Non-coding RNA Biomarkers

Inclusion Criteria: * Participants in Study "11-03 Ribolution" * Able and willing to give written informed consent * Not pregnant, as confirmed by pregnancy test Exclusion Criteria: * Past or present disease occurred since participation in "11-03 Ribolution", which as judged by the investigator, may affect the outcome of the study. * Serious, uncontrolled disease (including serious psychological disorders) likely to interfere with the study or impact on subject safety * Has experienced a significant upper or lower respiratory tract infection incl. moderate or severe exacerbation (requiring oral corticosteroid, antibiotics or hospitalisation) within the last 4 weeks. All courses of oral corticosteroids and antibiotics must be completed at least 4 weeks before study start * Clinically significant pathological findings in safety laboratory tests having an impact on study participation. * Actual drug or alcohol abuse. * Suspected inability to understand and follow protocol requirements, instructions, study-related restrictions, and to understand nature, scope, and possible consequences of the study. * Being a vulnerable subject (dependent, in detention, or without mental capacity)