Aspirin Twice a Day in Patients With Diabetes and Acute Coronary Syndrome

Inclusion Criteria: * Diabetes mellitus defined as (≥ 1 item) * Treated diabetes mellitus * 2 fasting glucose levels ≥ 7 mmol/l after admission * glucose level ≥ 11 mmol/l after admission (any moment) * HbA1C ≥ 6.5% OR * Factor of aspirin lack of efficacy defined as (≥ 1 item) * Obesity defined as BMI≥27kg/m2 * Waist circumference ≥ 88cm for women or ≥102cm for men * Index event occurring under chronic low dose of aspirin (\<300mg) AND \- Acute coronary syndrome defined as: * Acute coronary syndrome with ST-segment elevation (STEMI) is defined as chest pain (≥ 30min) with persistent ST-segment elevation in at least two contiguous leads (≥1mm) or a new left bundle-branch block and the intention to perform primary PCI or thrombolysis. * Acute coronary syndrome without ST-segment elevation (NSTEMI) is defined as universal myocardial definition: Detection of cardiac biomarker values elevation \[preferably cardiac troponin (cTn)\] with at least one value above the 99th percentile upper reference limit (URL) and with at least one of the following: * Symptoms of ischemia * New or presumed new significant ST-segment-T wave (ST-T) changes except ST elevation * Development of pathological Q waves in the ECG * Imaging evidence of new loss of viable myocardium or new regional wall motion abnormality * Identification of an intracoronary thrombus by angiography * included after the angiography showing stenosis ≥50% and before discharge * signed informed consent a…