Ixazomib Citrate, Lenalidomide, Dexamethasone, and Zoledronic Acid or Zoledronic Acid Alone After Radiation Therapy in Treating Patients With Solitary Plasmacytoma of Bone

Pre-registration eligibility criteria (Step 0) 1. Documentation of Disease: Histologic Documentation of Solitary Bone Plasmacytoma 1. For patients pre-registering after the completion of radiation therapy, documentation of a bone marrow aspirate and biopsy containing \<10% clonal plasma cells done at most 28 days prior to start of radiation therapy 2. For patients pre-registering before the start of radiation therapy, radiation therapy scheduled to begin at most 28 days after a bone marrow aspirate and biopsy were performed containing \<10% clonal plasma cells 3. Participants must have disease that is measurable by either serum or urine evaluation of the monoclonal component or by assay of serum free light chains or by minimal residual detection. Measurable disease is defined as one or more of the following: * serum M protein \> 0.5 G/DL, or * urine M protein \>200 MG/24H, and/or * serum FLC assay: involved FLC level \> 10 MG/DL with abnormal serum FLC ratio * ≥ 50 Plasma cells detectable by multicolor flow cytometry, at a sensitive level of 10\^-4 2. Age ≥ 18 years 3. ECOG Performance Status 0-2 Registration Eligibility Criteria (Step 1) 1. Documentation of Disease: 1. No lytic lesions on skeletal survey and whole body PET/CT other than a single lesion associated with solitary bone plasmacytoma within 28 days prior to registration. 2. Participants must have disease that is measurable by either serum or urine evaluation of the mono…