Inflammation-related Alterations in Neurocircuitry: Reversal With Levodopa

Inclusion Criteria: * Subjects have signed a current version of the Informed Consent and HIPAA documents prior to initiation of study procedures * Able to comprehend English * Diagnosis of Diagnostic and Statistical Manual of Mental Disorders (DSM)-V major depression and currently off antidepressant medication, unless otherwise approved by the PI or PI's designee * Depression as the primary axis I disorder * Negative pregnancy test for women of childbearing potential * Not breast feeding * At least two CRP tests conducted to establish reliability Exclusion Criteria: * Evidence of untreated or poorly controlled endocrine, cardiovascular, pulmonary, hematological, renal, or neurological disease * History of central nervous system (CNS) trauma or active seizure disorder requiring medication unless otherwise approved by principal investigator, or PI's designee * Current or history of migraines, glaucoma, melanoma, or bleeding disorder of any kind * Autoimmune or inflammatory disorder of any kind * Embedded metallic objects, prosthetics made of paramagnetic metals, aneurysmal clips and/or a history of claustrophobia * Chronic infection (e.g. hepatitis B or C or Human Immunodeficiency Virus infection) * Chronic use of agents known to affect the immune system including glucocorticoid therapy within the past 6 months, methotrexate within the past 1 year, chemotherapy of any kind (past or present), immunotherapy of any kind (past or present), aspirin or non-steroidal anti-inflammat…