UnknownNot Applicable

Open Lung Strategy in Critically Ill Morbid Obese Patients

United States21 participantsStarted 2016-04

Plain-language summary

The goal of this interventional crossover study in morbidly obese intubated and mechanically ventilated patients is to describe the respiratory mechanics and the heart-lung interaction at titrated positive end-expiratory pressure levels following a recruitment maneuver with transthoracic echocardiography and electric impedance tomography imaging.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * ICU admitted requiring intubation and mechanical ventilation * BMI ≥ 35 kg/m2 * Waist circumference \> 88 cm (for women) * Waist circumference \> 102 cm (for men) Exclusion Criteria: * Known presence of esophageal varices * Recent esophageal trauma or surgery * Severe thrombocytopenia (Platelets count ≤ 5,000/mm3) * Severe coagulopathy (INR ≥ 4) * Presence or history of pneumothorax * Pregnancy * Patients with poor oxygenation index (PaO2/FiO2\< 100 mmHg with at least 10 cmH2O of PEEP) * Pacemaker and/or internal cardiac defibrillator * Hemodynamic parameters: systolic blood pressure (SBP) \<100 mmHg and \>180 mmHg, or if SBP is between 100-180 mmHg on high dose of IV continuous infusion norepinephrine (\>20 μg per minute), or dobutamine (\>10 μg per minute), or dopamine (\>10 μg per Kg per minute), or epinephrine (\>10 μg per minute).

What they're measuring

Respiratory System Elastance

Timeframe: During study time points :baseline, PEEP incremental, PEEP decremental

Trial details

NCT IDNCT02503241

SponsorMassachusetts General Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2021-06-30

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