Safety, Tolerability and Activity of BIVV009 in Healthy Volunteers and Patients With Complement Mediated Disorders

Inclusion Criteria: Part A/B: * healthy male or female volunteers, age \>= 18 years old * if female, must be post-menopausal, surgically sterilized, or willing/able to use dual, redundant methods of contraception (e.g., barrier plus oral contraceptives) throughout the study * previously vaccinated against encapsulated bacterial pathogens (Neisseria meningitidis, Haemophilus influenzae, and Streptococcus pneumoniae) or willing to undergo vaccination * able to comprehend and to give informed consent * able to co-operate with the investigator, to comply with the requirements of the study, and to complete the full sequence of protocol-related procedures Part C: * male or female, age \>=18 years old * if female, must be post-menopausal, surgically sterilized, or willing/able to use dual, redundant methods of contraception (e.g., barrier plus oral contraceptives) throughout the study * previously vaccinated against encapsulated bacterial pathogens (Neisseria meningitidis, Haemophilus influenzae, and Streptococcus pneumoniae) or willing to undergo vaccination * able to comprehend and to give informed consent * able to co-operate with the investigator, to comply with the requirements of the study, and to complete the full sequence of protocol-related procedures * History of one of the following complement-mediated disorders: * bullous pemphigoid (BP) * cold agglutinin disease (CAD) * warm autoimmune hemolytic anemia (WAIHA) * active Antibody-Mediated Rejection (AMR) (acu…