Experimental animal data suggest that increasing breathing pattern variability in mechanical ventilation could be beneficial. Variable ventilation can be induced through the following modes: Neurally Adjust Ventilatory Assist (NAVA), Proportional Assist Ventilation (PAV) and Variable-Pressure Support Ventilation (V-PSV). These modes have not yet been compared to each other. Pilot observations in our department suggest a feasibility in patients. The objectives of the study are to compare the impact of PSV, NAVA, PAV and V-PSV on the variability of the breathing pattern, patient-ventilator asynchrony, risk of lung overdistension, gas exchange, and repartition of ventilation.
Age range
18 Years
Sex
ALL
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A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Coefficient of variation of the tidal volume (VT)
Timeframe: 1 hour
Coefficient of variation of the respiratory rate (RR)
Timeframe: 1 hour
Coefficient of variation of the inspiratory time (Ti)
Timeframe: 1 hour
Coefficient of variation of the electrical activity of the diaphragm (EAdi)
Timeframe: 1 hour
Coefficient of variation of the maximal inspiratory pressure (Ppeak)
Timeframe: 1 hour