Introduction: Glutamine (GLN) is the most abundant free amino acid in the body. It modulates immune cell function and is an important energy substrate for most cells (especially for enterocytes and lymphocytes) in critical patients. GLN levels significantly decreased during sepsis/critical illness leading to an increase in infectious complications, organ failure and mortality. Moreover, in cases of ischemia/reperfusion injury in the myocardium, GLN increases the levels of Adenosine triphosphate (ATP)/Adenosine diphosphate (ADP) ratio and prevents intracellular lactate accumulation. Recently, the perioperative effect of intravenous and oral GLN treatment been associated in lowering levels of cardiac injury markers such as Troponin-I (TROP-I) and the number of postoperative complications in patients who underwent Cardiopulmonary Bypass (CPB). The aim of the study was to analyze the oral dose of preoperative oral GLN treatment in patients who underwent CPB with extracorporeal circulation in Mexican patients.
Age range
40 Years – 70 Years
Sex
ALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
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Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Troponin-I
Timeframe: 1 hour before surgery.
Creatine Kinase
Timeframe: 1 hour before surgery
Creatine Kinase - Mb
Timeframe: 1 hour before surgery
Troponin-I
Timeframe: one hour after surgery.
Creatine Kinase
Timeframe: one hour after surgery.
Creatine Kinase - Mb
Timeframe: one hour after surgery.
Troponin-I
Timeframe: 12 hours after surgery
Creatine Kinase
Timeframe: 12 hours after surgery
Creatine Kinase - Mb
Timeframe: 12 hours after surgery
Troponin-I
Timeframe: 24 hours after surgery
Creatine Kinase
Timeframe: 24 hours after surgery
Creatine Kinase - Mb
Timeframe: 24 hours after surgery