Major Complications Related to PICC and Midline Insertion

Inclusion Criteria: • all patients aged 18-90 years (oncological, malignancy hematology, medical, surgical and critically ICU patients) in whom it was determined that PICC/Midline insertion was indicated. Exclusion Criteria: * renal insufficiency whose creatinine level was greater than 3.0 mg/dL or who were undergoing hemodialysis, * preexisting bacteremia (ie, existing positive blood cultures that had not been repeated with negative results); * preexisting venous thrombosis or known hypercoagulable states (such as protein C or S deficiency, Antithrombin deficiency, lupus anticoagulant); * axillary lymphonodi dissection or alteration of lymphatic drainage; * PICC and/or Midline insertion in a paretic arm; * patients who had been previously enrolled in the trial.