Stopped: Interim analysis results showed futility
The study is a substudy of the Enigma2 trial (NCT00430989) which aims at investigating the effectiveness and safety of nitrous oxide (N2O) in anaesthesia.The substudy focus is on postoperative cognitive disorders. Substudy Hypothesis: In patients undergoing anaesthesia for major surgery, administration of N2O will reduce postoperative cognitive disorders when compared with otherwise identically managed surgical patients not receiving N2O as a component of their anaesthesia.
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Memory, Executive function, Attention and psychomotor speed testing battery
Timeframe: Baseline before surgery
Memory, Executive function, Attention and psychomotor speed using CANTAB Cognitive testing battery at 7days following surgery
Timeframe: First assessment (7 days)
Memory, Executive function, Attention and psychomotor speed using CANTAB Cognitive testing battery at 3 months following surgery
Timeframe: Second assessment (3 months)