CompletedPhase 2

Amantadine to Speed Awakening After Cardiac Arrest

United States14 participantsStarted 2015-09

Plain-language summary

This study evaluates if amantadine will increase the rate of awakening in patients resuscitated from cardiac arrest but comatose (not following commands) after their resuscitation. Half of the participants will receive amantadine and the other will receive placebo.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Non traumatic cardiac arrest * Age 18 and older * Defibrillation and/or chest compressions by healthcare providers * Return of spontaneous circulation Exclusion Criteria: * Written do not attempt resuscitation (DNAR) reported to providers before randomization * Known prisoner or pregnancy * Lack of motor response to pain and absent N20 response on somatosensory evoked potentials prior to randomization * Initial CT demonstrating brain edema (defined as grey white ratio \<1.2) * Presence of malignant pattern on EEG at time of randomization * Next of kin unwilling to provide supportive care for at least one week after enrollment * Presently using other dopaminergic agent

What they're measuring

Rate of Awakening (Number of Patients Who Are Able to Follow Commands)

Timeframe: up to 28 days

Trial details

NCT IDNCT02486211

SponsorJon Rittenberger, MD

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2018-06-30

Results submitted2019-06-28

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