Brain Lesions in Relation to Motor Profiles of Children With Cerebral Visual Impairment. (NCT02480452) | Clinical Trial Compass
CompletedNot Applicable
Brain Lesions in Relation to Motor Profiles of Children With Cerebral Visual Impairment.
Belgium600 participantsStarted 2015-05
Plain-language summary
The overall goal of this research proposal is the early prediction of the emergence of CVI and its characteristics on the basis of neuroimaging data.
The different steps that will be taken to achieve this goal will be:
1. To characterize CVI deficits in children;
2. To correlate the CVI characteristics with their motor profiles;
3. To characterize brain lesions in children with CVI;
4. To link the motor profile, CVI profile and brain metrics of the children.
Over the last 10 years, 488 children with and without CP have consulted at the CVI clinic in Leuven. All these children had a comprehensive visual perceptual assessment, cognitive evaluation and an ophthalmological assessment. Summarizing these data results in a quantitative visual perceptual profile for each individual patient. The goal is to prospectively extend this database to a number of 600 children. The project's primary objective is to relate the presence of CVI to the motor profiles of these children.
Of these 488 children, 300 have an MRI available. The goal is to analyze the retrospective MRI data of this clinical group and to prospectively extend this database by reassuring newly registered children will receive MRI with DTI. This will allow the investigation of the correlation between the brain metrics and the CVI characteristics in a large cohort.
Who can participate
Age range
3 Years – 6 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* mental age between 3 y and 6 y
* suspicion of CVI
Exclusion Criteria:
* mental age below 3y
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This study looked at brain lesions and how they relate to motor profiles in children with cerebral visual impairment — what did the findings from tools like the L94 visual perceptual battery and the FIORI scale tell us about my child's specific type of visual impairment?
2Since this trial has already been completed, has my child's care team reviewed any published results that might help explain the connection between the brain lesion patterns they've seen on imaging and my child's current motor and visual difficulties?
3The study used neuroimaging alongside visual perceptual assessments — based on what this research found, would it be worth getting a detailed neuroimaging review for my child to better understand what might be driving their cerebral visual impairment?
4The FIORI scale was used to measure motor profiles in this study — is this something my child has been assessed with, and could it help guide decisions about physical or occupational therapy?
5Since this was an observational study rather than a treatment trial, are there any intervention trials or therapies that my child's doctor would now recommend based on what research like this has uncovered about the relationship between brain lesions and visual impairment in children?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.