CompletedPhase 3

Weaning of Norepinephrine Guided by the Dynamic Arterial Compliance in Cardiac Surgery Post Operative.

France130 participantsStarted 2014-10

Plain-language summary

After cardiac surgery, vasoplegic syndrome is a hemodynamic state characterized by profound hypotension associated with a decrease in systemic vascular resistance. The care of this disease is based on the intravenous administration of a vasopressor, usually norepinephrine. During the recovery phase, weaning of norepinephrine, is an important step in which any lack of preload (blood volume) initial or secondary can be, and increase tissue malperfusion.

Who can participate

Age range18 Years – 70 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Major patient ≥ 18 years * Patient operated a cardiac surgery for myocardial revascularization (CABG surgery) or surgical correction of valvular or combined surgery (CABG and valve disease) or surgery the ascending aorta and cardiac surgery with vasoplegic syndrome treated by norepinephrine * Signed consent * Affiliation to social assurance Exclusion Criteria: * Permanent atrial fibrillation * Treatment with dobutamine and/or epinephrine * Pregnant woman * Patient under guardianship or private public law * Internal pacemaker * Hypothermia * Patient refusal

What they're measuring

The duration of treatment with norepinephrine.

Timeframe: Day 28

Trial details

NCT IDNCT02479529

SponsorCentre Hospitalier Universitaire, Amiens

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2016-06

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