FibroTouch Non-invasive Evaluation of Liver Fibrosis and Cirrhosis

Inclusion Criteria: * Subjects with age 18-65 years, both gender * Subjects with history of HBV or HBsAg positive \> 6 months up to enrollment * Subjects with qualified liver biopsy specimens within three months (before or after) of Fibrotouch examination for pathological staging * Subjects without chemical therapy history of powerful medicine to lower enzyme in the two weeks before blood biochemistry tests (e.g. dimethyl diphenyl bicarboxylate and bicyclol) * Subjects must agree and sign the informed consent form Exclusion Criteria: * Subjects who are unable or unwilling to sign informed consent form * Subjects who have merger of hepatitis C, alcohol and non-alcoholic fatty liver diseases, autoimmune liver diseases, inherited metabolic liver diseases, biliary systemic diseases or liver and gall parasitic diseases * Subjects who have other serious chronic disorders or history of malignancy * Subjects with ALT ≥5 ULN in the past 1 month * Subjects with WBC\<3.5×10\^9/L, PLT\<60×10\^9/L, PTA\<60% * Subjects with DBIL≥1.5 ULN * Subjects with decompensated cirrhosis (especially the people with ascites) * Pregnant or lactating women, or women who has a pregnant plan and don't want to birth control in the study period * Subjects who have wound on the right upper abdomen recently * Subjects who have various space-occupying tumor or cyst in right liver * Subjects who have none or limited legal capacity