Non-invasive Risk Stratification of CR AMN/SSP

Inclusion Criteria: * Individuals capable and willing of proving satisfactory informed consent * Individuals with colonic lesions larger than 20mm * Individuals diagnosed with laterally spreading or sessile polyp morphology * Individuals schedules for screening colonoscopy and with no prior history of CRC * Ability and willingness to collect stool sample at home * Ability and willingness to undergo venepuncture procedure Exclusion Criteria: * Individuals not able or unwilling to provide informed consent * Individuals less than 18 year of age * Individuals who undergo an incomplete colonoscopy or resection, which raises doubt as to the status of the colon (post-hoc exclusion) * Individuals with a prior history of CRC * Individuals with a history of Irritable Bowel Disease (IBD), hereditary nonpolyposis colorectal cancer (HNPCC) or Familial adenomatous polyposis (FAP) * Individuals with bleeding diathesis * Pregnancy