CompletedNot Applicable

Intensive Versus Standard Hemodialysis CVC Dysfunction Protocol

Canada35 participantsStarted 2013-01

Plain-language summary

Central venous catheters (CVCs) are used for vascular access by approximately 56% of our 380 hemodialysis (HD) patients at the Capital Health Renal Program. The major complication of these catheters includes thrombosis and infection. Catheter locking solutions such as recombinant tissue plasminogen activator (rt-PA), Alteplase (Cathflo®) are used to treat and prevent clotting of the catheter during HD treatments and during the interdialytic period. Evidence to guide the use of rt-PA is limited. This quality assurance project will compare the effectiveness and cost of an intensive versus a standard catheter dysfunction protocol for rt-PA in HD patients.

Who can participate

SexALL

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Inclusion Criteria: * All adults undergoing HD with a tunneled CVC (both newly inserted CVCs as well as pre-existing CVCs) will be included. Exclusion Criteria: * Patients were excluded from using the CVC dysfunction protocols if they had a known allergy or intolerance to rt-PA. * A physician order to proceed with the CVC dysfunction protocols was required if they met one of the following criteria: * CVC line insertion or exchange within 72 hours; * any surgery, organ biopsy, obstetrical delivery within 72 hours; * active bleeding; bleeding disorders; hemoglobin decrease greater than 20 g/L over 2 weeks; * active pericarditis; arterial puncture within 48 hours; * bacteremia with positive blood cultures.

What they're measuring

Alteplase use

Timeframe: 9 months

Trial details

NCT IDNCT02474810

SponsorNova Scotia Health Authority

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2015-07

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