UnknownPhase 3

Posterior Compression Distraction Reduction （CDR）Technique in the Treatment of BI-AAD

China22 participantsStarted 2014-07

Plain-language summary

Posterior compression - distraction reduction technique （CDR） in the treatment of Basilar invagination associated with atlantoaxial dislocation

Who can participate

Age range

18 Years – 70 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age between 18-70 * Patients with cervical CT display that atlanto occipital fusion or partial fusion, Atlantoodontoid interval(ADI)\>\>3mm, odontoid tip over Qian line(CL)\>\>3mm. * Agreed to the surgical operation treatment * The patient can carry out clinical follow-up and agree to long-term clinical follow-up * Signed informed consent Exclusion Criteria: * Patients with traumatic atlanto-axial dislocation * Patients with rheumatoid atlantoaxial dislocation * Patients with a history of occipital cervical junction operation * Patients with severe cerebellar tonsillar hernia (reach the C2 margin), needed to remove tonsil of cerebellum * Patients during pregnancy and the postpartum period within 3 months * The life expectancy of \< 1 years * Severe dementia(MMSE\<18) * Severe renal failure (CR \> 2.5mg/dl) * Serious cardiovascular disease (such as unstable angina, heart failure) * Atrial fibrillation and other severe arrhythmia * Without the ability to sign the informed consent

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Record the patients' cervical JOA score, ASIA score

Timeframe: three days before surgery

The first follow-up after surgery Record the patients' cervical JOA score, ASIA

Timeframe: 3rd day post operation

ADI, CL and Cervicomedullary angle(CMA) by COP system and Compression Distraction Reduction， (CDR)

Timeframe: 3rd day post operation

Trial details

NCT IDNCT02463630

SponsorXuanwu Hospital, Beijing

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2016-06

Contact for this trial

Zan Chen, MD

13911712120 13911712120@163.COM

View on ClinicalTrials.gov More Basilar Invagination Associated With Atlantoaxial Dislocation trials

Who can participate

Age range

18 Years – 70 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Record the patients' cervical JOA score, ASIA score

Timeframe: three days before surgery

The first follow-up after surgery Record the patients' cervical JOA score, ASIA

Timeframe: 3rd day post operation

ADI, CL and Cervicomedullary angle(CMA) by COP system and Compression Distraction Reduction， (CDR)

Timeframe: 3rd day post operation