CompletedPhase 3

Regenerative Endodontic Procedure of Immature Permanent Teeth With L-PRF: a Pilot Controlled, Clinical Trial

Belgium29 participantsStarted 2014-09

Plain-language summary

This study evaluates the impact of autologous 'leucocyte and platelet rich fibrin' (L-PRF) on the periapical bone healing and further root development of infected immature permanent teeth. In the test group regenerative endodontic procedure (REP) is performed with L-PRF as scaffold, in the control group REP without L-PRF is performed .

Who can participate

Age range6 Years – 25 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Provision of Informed Consent * Permanent immature teeth with weak root canal walls (hopeless prognosis) * Patients younger than 25 years Exclusion Criteria: * \- Unlikely to be able to comply with the study procedures, as judged by the investigator. * Patients older than 25 years * Deciduous teeth * Permanent (immature) teeth that can be treated by a "regular" root canal treatment/ apexification * Known or suspected current malignancy * History of chemotherapy within 5 years prior to study * History of radiation in the head and neck region * History of other metabolic bone diseases * A medical history that makes REP unfavorable * Involvement in the planning and conduct of the study * Previous enrolment in the present study

What they're measuring

Amount of periapical bone healing, measured on intra-oral bidimensional radiographs.

Timeframe: 3 years

Trial details

NCT IDNCT02437708

SponsorUniversitaire Ziekenhuizen KU Leuven

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2019-08

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