CompletedNot Applicable

Cardiopulmonary Exercise Testing to Evaluate Pulmonary AVMs

United Kingdom39 participantsStarted 2011-04

Plain-language summary

Pulmonary arteriovenous malformations (PAVMs) are a rare vascular condition affecting the lungs. PAVMs lead to low blood oxygen levels, yet are very well tolerated by patients. This study will examine the exercise capacity of PAVM patients using formal cardiopulmonary exercise tests performed on a stationary bicycle.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Ability to provide informed consent * Healthy volunteers: no concurrent health reason to avoid exercise * Pulmonary AVMs: pulmonary AVMs confirmed by CT scan * Hereditary hemorrhagic telangiectasia without pulmonary AVMs: HHT according to current international consensus criteria, with no evidence of PAVMs on dedicated thoracic CT scan. Exclusion Criteria: * Inability to provide informed consent. * Any known cardiovascular abnormality including a history of syncope (faintness, dizziness, lightheadedness or loss of consciousness due to an abnormality of the cardiovascular system). * Current respiratory tract infection (eg a cold). * Pregnancy. * Claustrophobia or needle phobia

What they're measuring

Total body oxygen consumption in mls/min/kg, at peak exercise (VO2 max).

Timeframe: Same day (Day 1), at end of exercise study

Trial details

NCT IDNCT02436213

SponsorImperial College London

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2015-03

View on ClinicalTrials.gov More Pulmonary Arteriovenous Malformations trials