Whole Blood Specimen Collection From Pregnant Subjects

Inclusion Criteria: * Subject willing to provide consent to have up to 50 mL of whole blood collected at one or more monthly (≥25 days) clinic visits * Subject is pregnant carrying a singleton fetus of 10 to 26 weeks gestational age inclusive * Subject is 18 years of age or older * Subject is at an increased risk for one or more of the following: * fetal gene and chromosome abnormalities * congenital fetal infection * known to possess irregular blood group antigens (subject or father of the baby) * known to have some other condition amenable to noninvasive prenatal testing Exclusion Criteria: * Pregnancy is non-viable