CompletedNot Applicable

Altering Activation Patterns Post-stroke

United States96 participantsStarted 2015-11

Plain-language summary

This study evaluates a new rehabilitation approach for stroke survivors in the chronic phase of recovery in which the combination of drug therapy (cyproheptadine) and active movement practice (AMP) is used to encourage increased voluntary muscle control and strength.

Who can participate

Age range18 Years – 80 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Chronic, severe hand hemiparesis resulting from a single stroke (Chedoke- McMaster Stroke Assessment: Stage of Hand 2 or 3) * Single stroke occurring at least 6 months prior to enrollment * Spasticity * Capacity to provide informed consent Exclusion Criteria: * Excessive pain in paretic upper limb * Hemispatial neglect (as assessed by the Behavioral Inattention Test) * Apraxia (as assessed by the FABERS battery) * Botulinum toxin injection in the upper extremity within the past 6 months * Introduction of new anti-spasticity medication within the past 6 months * Orthopaedic impairments * History of seizure disorder * Other major health impairment

What they're measuring

Change in Mean Completion Time for Graded Wolf Motor Function Test (GWMFT)

Timeframe: baseline and 9 weeks (immediately post intervention)

Trial details

NCT IDNCT02418949

SponsorShirley Ryan AbilityLab

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2019-08

Results submitted2021-04-10

View on ClinicalTrials.gov More Stroke trials