CompletedNot Applicable

Mono-menotropins Versus rFSH Protocol on Embryo Quality

United States109 participantsStarted 2015-03

Plain-language summary

This study is for couples pursuing in vitro fertilization (IVF) with preimplantation genetic screening (PGS) of embryos to achieve pregnancy. The objective of this clinical trial is to study the effect of mono-menotropins for COS versus recombinant follicle stimulating hormone (rFSH) on cleavage-stage and blastocyst embryo quality after IVF. Embryo quality parameters include conventional embryo grade, early embryo viability assessment (Eeva) time-lapse parameters, and chromosomal aneuploidy rates after PGS. This pilot study is expected to significantly contribute to optimization of treatment regimens and stimulation protocols to optimize embryo quality.

Who can participate

Age range21 Years – 38 Years

SexFEMALE

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients undergoing IVF in an attempt to achieve pregnancy. * Day 2-4 Follicle Stimulating Hormone (FSH) \< 10 IU/ml, LH\< 12 IU/ml, and estradiol \<50 pg/ml on day 2-4 of menstrual cycle * Antimullerian Hormone \> 1.5 * Between 10 and 20 basal antral follicles on day 2-4 of the menstrual cycle * Body weight \>50 kg, with BMI \> 18 and \< 32 kg/m2 Exclusion Criteria: * Smokers * Polycystic ovarian disease * Endometriosis greater than Stage I * Testicular aspirated sperm * Preimplantation Genetic Diagnosis (PGD) for single gene disorder * Preimplantation Genetic Screening (PGS) banking cycles * Donor Egg Cycles

What they're measuring

Embryo Quality

Timeframe: Embryo quality will be assessed on day 3, 5 and 6 of culture

Trial details

NCT IDNCT02418533

SponsorMain Line Fertility Center

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2017-04

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