Vascularized Composite Allotransplantation for Treatment of Abdominal Wall Defects

Inclusion Criteria: * Abdominal wall defects as described above * Strong motivation to proceed with transplantation * Accepts dedicating at least 2 years towards extensive post transplant rehabilitation * Age between 18 and 60 years * Elapsed injury-to-transplant time of more than 6 months and less than 15 years * Reports sub-optimal outcome with conventional reconstructive procedures * Normal liver and kidney function tests: Exclusion Criteria: * Record of poor compliance * Unable to receive adequate follow-up care * Unable to receive immune suppression either due to geographic or financial limitations * Unable to follow strict rehabilitation schedule. * Documented psychological disorder(s) or incomplete psychological clearance * Impaired renal or hepatic function * Active cancer with or without metastases * Severe cardiac/pulmonary dysfunction or other severe irreversible/uncorrectable disease