UnknownNot Applicable

The Role of the Pulmonary Vasculature in the Fontan Circulation

Netherlands20 participantsStarted 2015-06

Plain-language summary

This study aims to explore the structural and functional characteristics of the pulmonary vasculature in adult Fontan patients. Objectives: * Determine the effect of pulmonary vasodilatation on indexed cardiac output during simulated exercise. * Characterization of structural properties of small pulmonary arteries.

Who can participate

Age range18 Years

SexALL

See this in plain English?

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Inclusion criteria: Fontan group * written informed consent * Clinical indication for cardiac catheterization Control group * written informed consent * Clinical indication for right heart catheterization * Absence of pulmonary vascular disease * Normal pulmonary vascular hemodynamic profile Exclusion criteria: Fontan group * Standard exclusion criteria for cardiac catheterization * Obstruction in Fontan conduit * Inability to measure a reliable cardiac index and PVR (rhythm instability, hemodynamic or anatomic reasons) Control Group \- No specific exclusion criteria apart from the standard exclusion criteria for right heart catheterization.

What they're measuring

vasodilatation

Timeframe: change in indexed cardiac output between baseline and after 10 minutes of pulmonary vasodilatation at heart catheterization

number of intimal lesions in small pulmonary arteries

Timeframe: baseline at heart catheterization

Trial details

NCT IDNCT02414321

SponsorUniversity Medical Center Groningen

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2024-06-30

Contact for this trial

Floris-Jan S Ridderbos, MD

+31503611506 f.j.s.ridderbos@umcg.nl

View on ClinicalTrials.gov More Congenital Heart Disease trials