CompletedNot Applicable

Advanced Understanding of Staphylococcus Aureus and Pseudomonas Aeruginosa Infections in EuRopE - ICU

Netherlands2,031 participantsStarted 2015-04

Plain-language summary

Intensive Care Unit (ICU) acquired pneumonia, including ventilator-associated pneumonia, is a frequently occurring health-care associated infection, which causes considerable morbidity, mortality and health care costs. Important pathogens causing ICU pneumonia are Staphylococcus aureus and Pseudomonas aeruginosa. The epidemiology of ICU pneumonia and patient-related and contextual factors is not fully described, but is urgently needed to support the development of effective interventions.

Who can participate

Age range18 Years

SexALL

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Inclusion criteria

✓. Participant is 18 years or older at the time of enrollment.
✓. Participant is on mechanical ventilation at ICU admission, or is (expected to be) within 24 hours thereafter, based on investigator's judgment.
✓. Expected stay in ICU is 48 hours or longer based on investigator's judgment.
✓. SA colonization status is known within 72 hours after start of first episode of mechanical ventilation and according to the result, the patient qualifies for enrollment.
✓. Written informed consent from subject / legally accepted representative within 72 hours after start of first episode of mechanical ventilation.

Exclusion criteria

✕. Previous participation as a subject in the study cohort of this study.
✕. Simultaneous participation of the subject in any preventive experimental study into anti-staphylococcus or anti-pseudomonas aeruginosa interventions.
✕. Expected death (moribund status) within 48h, or ICU discharge of the participant within 24h, at the moment of informed consent.

What they're measuring

Incidence of S. aureus ICU pneumonia

Timeframe: date of ICF until ICU discharge (on average 7 days after ICF)

Incidence of P. aeruginosa ICU pneumonia

Timeframe: date of ICF until ICU discharge (on average 7 days after ICF)

Trial details

NCT IDNCT02413242

SponsorJan Kluytmans

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2019-04-30

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