CompletedNot Applicable

Early-onset Obesity and Cognitive Impairment in Children With Pseudohypoparathyroidism

United States39 participantsStarted 2014-12-01

Plain-language summary

Pseudohypoparathyroidism type 1a (PHP1a) is a rare disease that causes childhood obesity and learning difficulties. This study will investigate eating behaviors and perform cognitive testing on children with PHP1a. The investigators will compare their results to those of healthy siblings and other obese children.

Who can participate

Age range6 Years – 18 Years

SexALL

See this in plain English?

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Inclusion Criteria: * Clinical diagnosis of PHP1a, sibling of a patient with PHP1a or matched obese control Exclusion Criteria (PHP1a): * Treatment with appetite-altering drug or initiation of a new weight loss program in the past 3 months * Type 2 diabetes Exclusion Criteria (Controls): * Obesity due to a genetic syndrome, growth hormone deficiency, untreated hypothyroidism, Cushing syndrome or exogenous glucocorticoid administration * Weight loss greater than 10% over the previous 6 months * Autism or other significant learning disorder * Type 2 diabetes * Other significant medical condition

What they're measuring

Intelligence Quotient

Timeframe: one day

Trial details

NCT IDNCT02411461

SponsorVanderbilt University Medical Center

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2017-01

Results submitted2018-02-28

View on ClinicalTrials.gov More Pseudohypoparathyroidism trials