CompletedNot Applicable

Cough in Reduced True Vocal Fold Mobility

United States15 participantsStarted 2015-04

Plain-language summary

This project is a first attempt to assess cough airflow dynamics and true vocal fold (TVF) adduction and abduction angles during voluntary cough to examine the effects of changes in glottal closure due to reduced mobility of one true vocal fold. The hypothesis of this study is that the incomplete glottal closure due to reduced vocal fold mobility will result in changes in true vocal fold adductory and abductory angles during cough and will result in changes to voluntary cough airflow parameters. This study results will contribute to the existing knowledge of the laryngeal contribution to cough airflow dynamics.

Who can participate

Age range40 Years – 75 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. Age between 40 and 75 years.
✓. Glottal insufficiency secondary to reduced TVF mobility confirmed with the endoscopic evaluation performed by an otolaryngologist.
✓. The ability to provide informed consent.
✓. No history of chronic obstructive pulmonary disease, lung cancer, and/or lung transplant.
✓. No history of neurodegenerative disease such as Parkinson's disease, multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), or progressive supranuclear palsy (PSP), Alzheimer's disease, or dementia.

Exclusion criteria

✕. Chest infection within one month prior to the study participation.
✕. History of the adverse reaction associated with laryngoscopy.

What they're measuring

Peak expiratory flow rate (PEFR)

Timeframe: baseline

True vocal fold maximum abduction angles in inspiratory phase

Timeframe: baseline

True vocal fold maximum abduction angles in expiratory phase

Timeframe: baseline

True vocal fold maximum adduction angles in compression phase

Timeframe: baseline

Peak expiratory flow rise time (PEFRT)

Timeframe: baseline

Cough volume acceleration (CVA)

Timeframe: baseline

Expiratory phase duration

Timeframe: baseline

Trial details

NCT IDNCT02407301

SponsorUniversity of Florida

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2016-02

View on ClinicalTrials.gov More Unilateral Vocal Cord Paresis trials

Plain-language summary

Who can participate

Age range40 Years – 75 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. Age between 40 and 75 years.
✓. Glottal insufficiency secondary to reduced TVF mobility confirmed with the endoscopic evaluation performed by an otolaryngologist.
✓. The ability to provide informed consent.
✓. No history of chronic obstructive pulmonary disease, lung cancer, and/or lung transplant.
✓. No history of neurodegenerative disease such as Parkinson's disease, multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), or progressive supranuclear palsy (PSP), Alzheimer's disease, or dementia.

Exclusion criteria

✕. Chest infection within one month prior to the study participation.
✕. History of the adverse reaction associated with laryngoscopy.

What they're measuring

Peak expiratory flow rate (PEFR)

Timeframe: baseline

True vocal fold maximum abduction angles in inspiratory phase

Timeframe: baseline

True vocal fold maximum abduction angles in expiratory phase

Timeframe: baseline

True vocal fold maximum adduction angles in compression phase

Timeframe: baseline

Peak expiratory flow rise time (PEFRT)

Timeframe: baseline

Cough volume acceleration (CVA)

Timeframe: baseline

Expiratory phase duration

Timeframe: baseline