UnknownPhase 4

Treatment of Intracranial Hypertension of Severe Tramatic Brain Injured Patients. Physiopathologic Effects of Neuromuscular Blocking Agents

France34 participantsStarted 2015-03-19

Plain-language summary

Severely brain injured patients are at high risk of intracranial hypertension. Among medical treatments (sedatives), neuromuscular blocking agents (NMBA) are recommended by french but not english speaking societies. Effects of NMBA are unknown. The present study is designed to compare the effects of NMBA versus placebo in the treatment of intracranial hypertension, and the underlying physiopathologic effects.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * \- Age over 18 * Mechanical ventilation and deep sedation * Severe traumatic brain injury * Intracranial hypertension (ICP \> 20 mmHg during \> 15 minutes) * Intracranial pressure monitoring * Hemodynamically stable Exclusion Criteria: * \- History of anaphylaxia with neuromuscular agents * Hemodynamic instability * Pregnant and/or breast feeding women

What they're measuring

area under the curve of the temporal evolution of intracranial pressure

Timeframe: at day 1

Trial details

NCT IDNCT02404779

SponsorUniversity Hospital, Clermont-Ferrand

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2022-03-19

Contact for this trial

Patrick LACARIN

04 73 75 11 95 placarin@chu-clermontferrand.fr

View on ClinicalTrials.gov More Traumatic Brain Injury trials