UnknownPhase 2

GDP in Frontline Chemotherapy for Patients With PTCL-NOS

China28 participantsStarted 2011-01

Plain-language summary

This study is to evaluate the efficacy and safety of GDP (gemcitabine, dexamethasone, and cisplatin) chemotherapy in patients with peripheral T-cell lymphoma-NOS as frontline treatment.

Who can participate

Age range18 Years

SexALL

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Inclusion criteria

✓. histological and imaging diagnosis of PTCL-NOS based on immunophenotypic and morphologic criteria according to the 2008 World Health Organization classification of lymphomas;
✓. newly-diagnosed patients with no prior systemic chemotherapy or stem-cell transplantation treatment.
✓. age ≥ 18 years;
✓. life expectancy of more 3 months;
✓. Eastern Cooperative Oncology Group (ECOG) performance status 0-2;
✓. at least one measurable lesion;
✓. adequate hematologic, hepatic, and renal functions: absolute neutrophil count ≥ 1.5×109/l, platelet count ≥ 100×109/l, total bilirubin ≤ 1.5 × upper limit of normal, AST and ALT ≤ 2 × upper limit of normal, and creatinine ≤ 1.5 mg/dl;
✓. informed consent.

Exclusion criteria

✕. patients who received prior treatment;
✕. pregnant or breastfeeding women and women of childbearing potential not employing adequate contraception;
✕. patients with second primary cancer (except, adequately treated non-melanoma skin cancer, curatively treated in-situ cancer of the cervix, or other solid tumors curatively treated with no evidence of disease for ≥5 years)
✕. patients with defect of central nervous system (CNS) or any psychiatric disorders and CNS metastases
✕. other serious illness or medical conditions A. Clinically significant cardiac disease (uncontrolled congestive heart disease despite treatment \[NYHA class III or IV\], symptomatic coronary artery disease, unstable angina or myocardial infarction, conduction abnormality like grade 2 AV block, serious arrhythmia needed for medication, uncontrolled hypertension) within 6 months prior to study entry B. Liver cirrhosis (≥ Child-Pugh class B) C. History of significant neurologic or psychiatric disorders including dementia or seizures D. Active uncontrolled infection E. Other serious underlying medical conditions which could impair the ability of the patient to participate in the study

What they're measuring

overall response rate

Timeframe: 4-6 cycles

Trial details

NCT IDNCT02404571

SponsorChinese Academy of Medical Sciences

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2016-12

Contact for this trial

Mei Dong

(86)13811929322 dongmei030224@163.com

View on ClinicalTrials.gov More Lymphoma, T-Cell, Peripheral trials