CompletedPhase 2/3

Use of Letrozole Pretreatment With Misoprostol for First-Trimester Medical Abortion

Egypt423 participantsStarted 2015-03

Plain-language summary

The purpose of this study is to compare the success rate of letrozole and misoprostol versus misoprostol alone for medical termination of first trimester pregnancy.

Who can participate

Age range18 Years

SexFEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Maternal age more than 18 years old (age of legal consent). * Gestational age less than 13 weeks. * Hemoglobin \>10 g/dL. * BMI between 25 kg/m2 and 35 kg/m2. * Missed abortion. * Living fetus with multiple congenital malformations incompatible with life. Exclusion Criteria: * Maternal age less than 18 years old. * Gestational age more than 12 weeks. * Hemoglobin \<10 g/dL. * Anencephaly. * Fibroid uterus. * BMI less than 25kg/m2 and more than 35kg/m2. * Coagulopathy. * History or evidence of adrenal pathology. * Previous attempts for induction of abortion in the current pregnancy. * Allergy to misoprostol or letrozole. * Medical disorder that contraindicate induction of abortion (e.g. heart failure).

What they're measuring

Incidence of complete abortion

Timeframe: 1 week

Trial details

NCT IDNCT02401425

SponsorAin Shams University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2015-09

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