South Asians have a much higher risk of diabetes compared to Europeans and investigators don't know why this is. Investigators think that South Asians' capacity to store fat safely under the skin is lower than Europeans, so they start to store fat around internal organs and in liver and muscle, and at lower body weights than Europeans. These increased levels of internal fat storage are thought to increase risk of diabetes. The purpose of the study therefore is to investigate whether there are differences with weight gain and weight loss in fat storage, fat cell function and metabolic risk factors, in South Asians compared with Europeans. Investigators will compare South Asian and European men at the start of the study, after they have gained about 7% body weight, and again after they have lost 7-15% body weight (from peak weight) to see how gaining and losing weight affects fat storage within the body and the function of fat cells. Investigators will also assess the effect of weight gain and weight loss on metabolism, fitness and risk factors for diabetes and heart disease.
Age range
18 Years – 45 Years
Sex
MALE
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Change in body metabolism after gaining 7% body weight and after losing 7% of body weight
Timeframe: Weight gain assessment made after an expected average of 5 weeks and weight loss assessment after 12 weeks
Change in visceral adipose tissue after gaining 7% body weight and after losing 7% body weight
Timeframe: Weight gain assessment made after an expected average of 5 weeks and weight loss assessment after 12 weeks
Change in subcutaneous adipose tissue after gaining 7% body weight and after losing 7% body weight
Timeframe: Weight gain assessment made after an expected average of 5 weeks and Weight loss assessment after 12 weeks
Change in liver adipose tissue after gaining 7% body weight and after losing 7% body weight
Timeframe: Weight gain assessment made after an expected average of 5 weeks and Weight loss assessment after 12 weeks
Change in adipose cell morphology after gaining 7% body weight and after losing 7% body weight.
Timeframe: Weight gain assessment made after an expected average of 5 weeks and weight loss assessment after 12 weeks
Change in adipose cell insulin sensitivity after gaining 7% body weight and after losing 7% body weight
Timeframe: Weight gain assessment made after an expected average of 5 weeks and weight loss assessment after 12 weeks
Change in adipose cell function after gaining 7% body weight and after losing 7% body weight
Timeframe: Weight gain assessment made after an expected average of 5 weeks and weight loss assessment after 12 weeks